How RenalGuard Works

RenalGuard Therapy® works by safely inducing higher rates of urine than are possible with standard diuretics alone.  RenalGuard achieves these urine rates by matching the patient's urine output milliliter-for-milliliter, minute-by-minute.  The accurate automate balancing of RenalGuard reduces the risk of over- or under-hydration relative to standard infusion.

The animation demonstrates how RenalGuard Therapy operates in practice to achieve these high urine flows.

Theory of Operation
Iodinated Contrast is necessary to allow many of the life-saving procedures that are performed in cath labs around the world every day.  Unfortunately, that same contrast can also cause damage to a patient's kidney if it remains in the kidney for very long.  RenalGuard Therapy has been designed to reduce this damage through the following means:

  • increasing urine rates, and thus increasing the rate contrast is expelled from the kidney
  • increasing the patients level of hydration, which should dilute the contrast in the kidney
  • reducing the workload of the kidney, which will reduce the oxidative stress on nephrons.  This should make the nephrons less susceptible to damage from contrast.

The animation below demonstrates a simplified version of this theory:






RenalGuard is CE-marked for the intended use of temporary (up to 14 days) replacement of urine output by infusion of a matched volume of sterile replacement solution to maintain a patient’s intravascular fluid volume. The RenalGuard System is not intended for infusion of blood, blood components, medications, or nutritional fluids. All treatments administered via The RenalGuard System must be prescribed by a physician. RenalGuard Solutions, Inc. reserves the right to modify the specifications and features described herein, or discontinue manufacture of the product described at any time without prior notice or obligation.

Caution - Investigational Device, Limited By United States Law to Investigational Use.